Why You Should Rotate Between Botox, Xeomin, and Dysport

To temporarily reduce the appearance of wrinkles and fine lines on the face, the neuromodulators Botox, Xeomin, and Dysport are used. These medications temporarily paralyze the muscles that cause wrinkles, making the skin appear smoother and more youthful.

Botox, Xeomin, and Dysport are made from the same active ingredient, botulinum toxin type A. Botox is the brand name for botulinum toxin type A produced by Allergan. Xeomin is the brand name for botulinum toxin type A produced by Merz. Dysport is the brand name for botulinum toxin type A produced by Galderma. Despite being similar, these three neuromodulators have some key differences.

One significant difference between these three neuromodulators is their formulation. Botox is made from a complex protein molecule. In contrast, Xeomin is made using a unique manufacturing process that removes all other proteins from the botulinum toxin, making it a “naked” or “pure” form of the toxin. This means that Xeomin is free from any additional proteins or additives. Dysport is also made from a more purified form of botulinum toxin type A, but it is formulated differently than Xeomin.

Rotating different types of neuromodulators can be beneficial because it can help to prevent the development of tolerance, which is when the body becomes less responsive to a substance over time. A higher treatment dose is needed when tolerance develops to achieve the same effect. This can lead to increased side effects as well. Rotating different types of neuromodulators can help prevent tolerance by providing the body with various neuromodulators to respond to.

In conclusion, Botox, Xeomin, and Dysport are all neuromodulators that temporarily reduce the appearance of wrinkles and fine lines on the face. It is beneficial to rotate neuromodulators to ensure the best results over time.

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Brandon Kirsch, MD

Brandon Kirsch, MD, FAAD, is a board-certified dermatologist specializing in clinical drug development and medical innovation. He is the founder of Kirsch Dermatology in Naples, Florida and is also the Chief of Dermatology at the Naples Community Hospital.